In a large saucepan on medium heat, add pancetta and fry until golden brown, stirring often. Once golden brown, use a slotted spoon to remove from the oil. Add 2 tablespoon of EVOO. Then stir in the onion, celery, and carrots. Add a pinch of salt and stir. Saute the vegetables until soft and the onions translucent. Stir in the garlic and saute for 2 more minutes.
Add the bison, directly to the vegetables. Break apart the bison with a spoon. Add a pinch of salt. Cook until just browned. Then add tomato paste and stir throughout. Allow it to cook for 2-3 more minutes. Then add the red wine and bring it to a simmer. Simmer until the red wine is almost completely absorbed.
Using your hands or an immersion blender, crush the plum tomatoes. Pour into the sauce and return the sauce to a simmer. Add the pancetta, basil, and a pinch of salt. Simmer for 2-3 hours.
In a large pot, bring water to a boil. Add salt and your pasta. Boil as directed. Add ½ cup of pasta water to the ragu and stir. Then add your pasta to the sauce and stir until combined. Serve with pecorino romano cheese!
Notes
Add the pancetta to the cold pan and bring it to medium heat to perfectly render the fat and get golden brown pancetta.
Taste the sauce occasionally to see if more salt needs to be added. It is normal to add salt through the cooking process.